CARALLUMA (CARALLUMA ADSCENDENS)
Where did he come from?
Caralluma is used in herbal medicine, in the form of a fluid extract, as a moderator of appetite, especially in cases of bulimia and for its queer properties.
Caralluma is traditionally used to treat obesity and overweight. The used parts of the plant are the aerial parts.
Native to India, it grows on dry soils in India, Africa and southern Europe.
The Indians chewed pieces of caralluma to suppress hunger during hunting periods. This succulent plant (a plant capable of storing water in its stems and leaves, resistant to drought) is used in southern India to suppress appetite, thirst and increase resistance. Caralluma is listed as a food to fight famine in the list of Indian medicinal plants.
The range is from India and Sri Lanka to the Arabian Peninsula, to North Africa to the Sahel. It had a magical use to exorcise the disease, as well as in traditional medicine against gastric disorders and parasitosis.
Its Arabic name qahr al-luhum (carnal wound, abscess) describes the putrid smell of its flowers.
How can we describe it botanically?
Similar to a shrub that does not exceed 30 cm in height, the caralluma has angular stems, 1.5 to 3 cm thick, with rudimentary leaves resembling thorns. Its star-shaped flowers, black, purple, yellow or red, appear in summer or autumn. We use the air parts in medicine.
What is it made of?
Caralluma contains pregnane glycosides, megastigmane flavone glycosides, luteoline and saponosides.
What are its main pharmacological properties?
The caralluma is from the same family as the Hoodia gordonii. Although its origin is different, its appetite suppressant action is similar. The compounds responsible for this action appear to be pregnaneglycosides. These active ingredients abundant in caralluma send a signal of satiety to the brain and more precisely to the hypothalamus responsible for controlling hunger.
Caralluma also inhibits enzymes involved in lipogenesis, including citrate lyase.
A randomized, double-blind, placebo-controlled clinical study, conducted on overweight adults (62 volunteers of both sexes aged 25 to 60 years) (BMI>25), shows the action of caralluma (1g of dry hydroalcoholic extract of aerial parts of caralluma per bone/day for 60 days) on different parameters: body weight, body mass index (BMI), waist and hip circumference, percentage of fat mass, appetite.
There have been significant decreases (p<0,01) plus forte chez le groupe traité par rapport au groupe placebo du tour de taille et de l’appétit (diminution de 20% après 2 mois de traitement).
This appetite-moderating action is thought to be due to prenagne glycosides.
A study conducted by the PhytoPrevent Laboratory demonstrated the lipolytic effect of caralluma, by evaluating the lipolytic activity of a Standardized Fresh Plant Extract (EPS – obtained using the PhytoStandard extraction process) on exdipose tissue explants in culture (ex vivo).
Water and alcoholic extracts of whole plants (oral) of Caralluma (250mg/kg) reduce blood glucose levels of diabetic rats (P<0,001).
Anti-inflammatory activity was assessed by measuring the resorption of edema (induced by carragenin) on rats taking either luteoline-4-0-neohesperidoside (CA-1), extracted from fresh Caralluma, or ibuprofen.
What are the indications of the Caralluma?
- Metabolic syndrome
- Accompanying diets, moderating appetite effect
- Lipolysis and BMI stabilization in obese or overweight subjects
- Reduction of waist circumference and normo-glycemic action in patients with android morphotype (metabolic syndrome, non-insulin-dependent diabetes)
- Eating disorders (bulimic compulsions, hyperphagia)
What are the job precautions?
- Under-indicated in pregnant or lactating women, as well as in children under 12 years of age
- No drug interactions have been reported to date
How to take it and at what dosage?
In masterful preparation
Here is the dosage of Fluid Extracts of Fresh Plants Standardized in Glycere solution (EPS):
1 c. coffee morning and evening for 1 month, renewable 3 months, to dilute in a large glass of water.
- Appetite moderation and weight loss accompaniment: Caralluma – Guarana
- Diuresis and lipolysis (cellulite): Caralluma – Orthosiphon – Mélilot