THE MARIE CHARDON (Silybum marianum L.)
Where did he come from?
The marie thistle is a major liver plant. Its hepato-protective and bile duct actions make it an ally of choice for the aftermath of toxic chemical aggressions.
Ancient Greeks already used thistle to treat liver and bile disorders. In the Middle Ages, the plant was used to flush out "melancholy" or "black bile" which was otherwise associated with various liver-borne diseases. Today, its use remains linked to the treatment of various liver and bile disorders. It is also native to the uneducated places of southern Europe, northern Africa and West Asia.
According to popular belief, the white marks of the leaves come from the milk of the Virgin breastfeeding her child, from which her name would come from.
How can we describe it botanically?
Although the thistle marries is rather a biennial herbaceous plant up to a metre high, its leaves nevertheless bear white marbling and its flowers, tubulous, purple are gathered in a terminal capitula. The part used mainly in medicine is the fruit (akene) devoid of its egrets.
What is it made of?
The marie thistle is composed in short of flavonolignanes, flavonoids, phenolic derivatives, tocopherol, sterols, lipids (20 to 30%), proteins and sugars.
What are its main pharmacological properties?
In patients with, for example, type II diabetes, taking silymarine reduces glycated hemoglobin, fasting blood sugar, total cholesterol, LDL cholesterol, triglycerides, ASAT and ALAT compared to placebo. Similarly, in people with non-insulin-dependent diabetes associated with alcoholic cirrhosis, silymarine reduces lipid peroxidation of cell membranes and insulin resistance.
The marie thistle is then traditionally used to promote lactation.
Hepatoprotective by flavonolignanes, Marie thistle, however, has activities related to various receptor and transporter functions located in cell membranes by modulation of TNF-alpha and selectins, it also possesses antioxidant properties, as well as inhibitory effects of the pathway of lipoxygenase, nitric oxide synthase inducible iNOS, nuclear factor kappa B and collagen synthesis by effects mediated by DNA.
Marie thistle is reputed to be the antidote to phalloid amanite poisoning, a meta-analysis of 452 patients with ploid amanitis poisoning show a significant difference in mortality in favour of silibinin (mortality 9.8% versus 18.3% with standard treatment, p <0,01), la silibinine prévient l’absorption des amatoxines de l'amanite phalloïde par les hépatocytes, protégeant ainsi le tissu hépatique, elle stimule les ARN polymérases ADN-dépendantes, augmentant la synthèse d’ARN.
In addition, it has anti-cancer properties of silymarine, anti-inflammatory and anti-metastatic by modulation of specific proteins.
Silymarine is anti-cancer activity through multiple mechanisms: carcinogenesis initiation, promotion and progression. Its anti-metastatic effect is also notable. As a result, numerous clinical studies show a reduction in the toxicity of chemotherapy drugs in combination with silymarine.
Silymarine, however, inhibits the proliferation of tumor cells from various cancers.
What are the indications of the married Thistle?
- Liver congestion
- Difficult digestions
- Gallbladder conditions
- Hepatobiliary insufficiency
- Acute and chronic hepatitis
- Nervous depression
- Gastralgia and inapperence during chemotherapy
- Metabolic syndrome with mild hypertension
- Non-alcoholic fatty liver disease
What are the job precautions?
- Rare cases of mild gastrointestinal disorders
- Contraqual in case of bile duct obstructions
- Caution in case of allergy to asteraceae
Are there risks of drug interactions?
Like all substances containing active ingredients, the risk of drug interactions is all in all to consider.
As thistle marries are no exception to this rule, here is a list of drug interactions to consider:
- Risk of drug interaction in concomitant use with codeine, norcodeine, chemotherit therapeutic treatments, anti-arrhythmics, statins, calcium inhibitors, anti-infective, immunosuppressants, H1 anti-histamines, benzodiazepines, anticancers.
How to take it and at what dosage?
In masterful preparation
In masterful preparation:
Here is the dosage of Fluid Extracts of Fresh Plants Standardized in Glycere solution (EPS):
1 c. coffee morning and evening for 1 month, renewable 3 months, to dilute in a large glass of water
- Hepatoprotection (alcohol, chemotherapy…) : Marie Thistle – Desmodium – Black Radis
- Gastralgia and inapperence during chemotherapy: Thistle marries – Turmeric – Mélisse
- Metabolic syndrome with mild hypertension: Thistle marries – Olivier – Hawthorn
- Non-alcoholic fatty liver disease: Thistle marries – Turmeric