LE GRIFFONIA (Griffonia Simplicifolia)
Where did he come from?
Restoring the therapeutic properties of griffonia requires the fullness and integrity of the seed's components. Only an alcoholic extraction with varying degrees of dilution, sheltered from light and at low temperature, actually allows the preservation of all its components.
Griffonia is widespread in tropical Africa. Africans have been using it in traditional medicine for many years. For example, leaves are used to remove lice, and roots and stems are used as chewing sticks. Westerners were interested in this plant only from the 1970s especially for its high levels of 5-HTP, precursor of serotonin and melatonin.
How can we describe it botanically?
The griffonia is actually a sarmentous shrub with a trunk up to 7 cm in diameter. The plant part is between 3 and 10 meters high. The leaves are whole, ovable and hairless. The flowers are grouped into grey tomenting clusters. The pods are also obliquely ovoid and swollen.The part used in medicine is the seed.
What is it made of?
The griffin composes in short 5-hydroxy-tryptophan, alkaloids and lectins.
What are its main pharmacological properties?
Most studies have been conducted primarily on the activity of 5-HTP, the main constituent of Griffonia simplicifolia.
In vivo, in patients with unipolar and bipolar disorders, taking 5-HTP improved disorders in 69% of cases without side effects.In depressed patients, the combination of a tricyclic anti-depressant and 5-HTP significantly improves the Hamilton test score.
In migraine patients, taking 5-HTP for 6 months is in short the same effectiveness as a reference anti-migraine (methysergide). 5-HTP is also comparable in effectiveness to a blocker and significantly reduces the frequency of migraine attacks and painkiller use.
Several studies have highlighted the hypnogenic effect of 5-HTP. In normal patients, the administration of 5-HTP significantly increases the duration of REM sleep. Especially in moderately insomniac patients, low doses of 5-HTP significantly improves sleep duration and depth.
In obese women (30<IMC<40), la prise de 5-HTP comparé à un placebo permet une perte significative de poids avec diminution spontanée de l’apport calorique journalier (3220 Cal/j à 1879 Cal/j) et notamment de l’apport de glucides (diminution de 50%).
A malfunction of the nociception modulation system appears to occur especially in cases of fibromyalgia. In fibromyalgic patients, reduced levels of serotonin metabolites in cerebrospinal fluid have been reported suggesting the involvement of serotonin deficiency in the pathogenesis of the disease. However, an elevation of substance P, responsible for the increase in pain, was observed in the central nervous system and peripheral nerves. In fibromyalgic patients, the administration of 5-HTP for 30 days allowed the reduction of the number of painful points and their intensity but also of muscle rigidity at sunrise and anxiety.
What are the Indications of Griffonia?
- Various addictions and addictions
- Serotonin depression
- Sleep disorders, nocturnal awakenings…
- Migraine on anxious terrain (background treatment)
- Accompanying treatment for fibromyalgic pain
What are the job precautions?
- Under-indicated in pregnant or lactating women
- Contraindicated in children with Down's syndrome (risk of seizures), as well as in cases of small intestine carcinoid tumours and scleroderma
- Risk of mild gastrointestinal disorders (including nausea), usually temporary
Are there risks of drug interactions?
Like all substances containing active ingredients, the risk of drug interactions should be taken into account.
The griffonia does not deviate from this rule, here is the list of drug interactions to consider:
- Avoid association with carbidopa, St. John's wort and antidepressants
How to take it and at what dosage?
In masterful preparation:
Here is the dosage of Fluid Extracts of Fresh Plants Standardized in Glycere solution (EPS):
1 to 2 càc/d at bedtime for 3 months to be renewed depending on the clinic
1 to 2 tbsp for 15 days to be renewed depending on the clinic
1 to 2 càc/d at bedtime for at least 3 months to be renewed depending on the clinic
- Eating disorders (snacking, sweet compulsions at the end of the day…) In: Griffonia 1/2 – Caralluma 1/2
1 to 2 càc/d around 5 p.m. for 3 months to be renewed depending on the clinic
1 to 2 càc/d at bedtime, 5 days a week for 3 months to be renewed depending on the clinic