Semaglutide + Tirzepatide: Our natural alternatives for obesity and diabetes

In a world where obesity and type 2 diabetes are affecting more and more people, the search for effective solutions is paramount. Ozempic (semaglutide), Zepbound and Mounjaro (tirzepatide) represent a major step forward in this quest. Although these drugs differ in their chemical composition, they share a common objective: to help patients manage their weight and control their blood sugar levels.

Ozempic, a formulation of semaglutide developed by Novo Nordisk, is used primarily for the treatment of type 2 diabetes. It works by mimicking the effect of GLP-1 hormones, helping to regulate blood sugar levels. More recently, its effectiveness in weight loss has been recognised, broadening its field of application.

Zepbound and Mounjaro, containing the active ingredient tirzepatide, are more recent drugs. Tirzepatide is a dual agonist of the GIP and GLP-1 receptors, offering dual action in the treatment of type 2 diabetes and obesity. Recent studies, such as the SURMOUNT trial, have demonstrated the significant efficacy of tirzepatide in reducing body weight and improving glycaemic control in obese or overweight patients.

In this article, we will explore these revolutionary drugs in detail, examining their mechanism of action, efficacy and safety profile. We will also discuss potential natural alternatives, to provide a comprehensive perspective on the treatment options available in 2023 for obesity and type 2 diabetes. Our aim is to provide clear and accurate information to help readers better understand these drugs and make informed decisions about their health.

[ Disclaimer: The information in this blog post is provided for general information purposes only and does not constitute professional medical advice. Ozempic and Mounjaro are prescription-only medicines and may under no circumstances be sold without a prescription, either in an online pharmacy or in a pharmacy. Any decision regarding their use must be taken in consultation with a qualified healthcare professional. The information presented here is based on knowledge available up to the date of publication and may not reflect the latest scientific advances. It is always necessary to consult a doctor or other qualified healthcare professional before starting, modifying or interrupting any medical treatment. Under no circumstances should the information contained in this article be used to diagnose or treat a medical condition ]

Understanding how Ozempic, Zepbound and Mounjaro work

In order to make an informed choice among the treatments available for obesity and type 2 diabetes, it is essential to gain an in-depth understanding of drugs such asOzempic, Zepbound and Mounjaro, examining their mechanisms of action, proven efficacy and safety profile.

I. Ozempic and Semaglutide

Ozempic, a formulation of semaglutide, is a revolutionary treatment for type 2 diabetes and obesity, whose mechanism of action, efficacy demonstrated in clinical studies, and associated side effects and safety issues we will explore.

Mechanism of action

Ozempic, known scientifically as semaglutide, is a GLP-1 receptor agonist. It works by mimicking the body’s natural GLP-1 hormone, which is released in response to food. This hormone plays a key role in regulating appetite and blood sugar levels. Semaglutide works by stimulating insulin secretion and reducing the release of glucagon, which helps to lower blood sugar levels. It also delays gastric emptying, helping to increase the feeling of satiety.

Efficacy and clinical studies

Clinical studies have shown that Ozempic is particularly effective in reducing blood sugar levels in patients with type 2 diabetes. It has also demonstrated a significant capacity to induce weight loss in these patients. These results are due in particular to its effects on appetite and metabolism. Studies have also highlighted Ozempic’s effectiveness in reducing the cardiovascular risks associated with type 2 diabetes.

Side effects and safety considerations

Like any medicine, Ozempic can cause side effects. The most common include gastrointestinal disturbances such as nausea, vomiting, diarrhoea and constipation. These effects are generally mild and tend to diminish over time. Concerns have also been raised about the potential risk of pancreatitis and C-cell thyroid tumours. However, these risks appear to be low and must be balanced against the substantial benefits of the drug, especially under appropriate medical supervision.

II. Zepbound and Mounjaro (Tirzepatide)

Zepbound and Mounjaro, two trade names for tirzepatide, represent an innovation in the treatment of obesity and type 2 diabetes. This section will detail their unique mechanism of action, the results of landmark clinical studies, as well as their safety profile and observed side effects.

Mechanism of action

Tirzepatide, the active ingredient in Zepbound and Mounjaro, is a dual agonist at the GIP and GLP-1 receptors. It acts by stimulating these two receptors, which are present in the pancreas and the brain, leading to an increase in insulin secretion and a decrease in glucagon secretion. This action helps to control blood sugar levels more effectively. In addition, tirzepatide slows gastric emptying and influences the satiety centres in the brain, helping to reduce appetite and promote weight loss.

Results of the SURMOUNT studies

The SURMOUNT studies were conducted to evaluate the efficacy of tirzepatide in the management of obesity and type 2 diabetes. These studies showed significant weight loss in participants treated with tirzepatide. For example, the SURMOUNT-2 study showed body weight reductions of -12.8% and -14.7% for the 10 mg and 15 mg doses, respectively, compared with -3.2% for placebo. These results demonstrate the efficacy of tirzepatide in significantly reducing body weight and improving glycaemic control.

Safety profile and side-effects

The safety profile of tirzepatide is generally considered to be favourable, although it is associated with side effects, mainly gastrointestinal. The most common effects include nausea, vomiting and diarrhoea, which are mostly mild to moderate and tend to diminish over time. Caution is advised in patients with a history of gastrointestinal or pancreatic disease. Overall, the benefits of tirzepatide in the management of obesity and type 2 diabetes outweigh the potential risks, but close medical supervision is advised.

III. Limitations and side-effects of GLP-1 and GIP-based treatments

Peptides such as GLP-1 and GIP, used in the treatment of obesity and type 2 diabetes, have shown promising results. However, it is essential to take account of their limitations and side effects if they are to be used appropriately and safely.

Limitations

Effectiveness and adherence to treatment: Although drugs such as tirzepatide have shown significant efficacy, their effectiveness may vary between individuals. In addition, a study by Weill Cornell Medicine found that stopping the drug can lead to weight regain, underlining the importance of continued adherence to treatment to maintain benefits (7).
Cost and accessibility: The high cost of these drugs may limit their accessibility for many patients. Availability may also vary according to health insurance reimbursement policies.
Duration of treatment: These treatments often require long-term use to maintain the results obtained, which can pose challenges in terms of long-term monitoring and cost management.
Lack of long-term data: Despite the positive short- and medium-term results, there is a lack of data on the long-term effects and safety of these treatments.

Side effects

Gastrointestinal disorders: The most common side effects associated with GLP-1 and GIP agonists are gastrointestinal disorders, including nausea, vomiting and diarrhoea. These effects are generally mild to moderate, but may be troublesome for some patients (3).
Risk of Pancreatitis: There is a potential risk of pancreatitis, although rare, associated with the use of these drugs. Medical supervision is therefore necessary to detect any worrying symptoms at an early stage.
Injection Site Reactions: As these drugs are often administered by injection, injection site reactions may occur.
Drug Interactions and Contraindications: It is crucial to consider potential interactions with other drugs and contraindications, particularly in patients with a history of gastrointestinal disease.

What are the natural alternatives to Semaglutide and Tirzepatide?

Let’s explore some effective natural alternatives for managing weight and diabetes, with a focus on nutrition, physical activity and natural remedies

The importance of a balanced diet cannot be underestimated in the management of obesity and type 2 diabetes. A well-structured diet not only helps to control weight, but also plays a crucial role in regulating blood sugar levels.

Key foods for weight and diabetes management :

Fibre fibre-rich foods such as vegetables, whole fruit, legumes and whole grains are essential. Fibre slows digestion, improving blood sugar control and promoting satiety.
Lean protein sources of lean protein such as fish, poultry, lentils and tofu help build muscle and promote satiety without adding excessive saturated fat.
Healthy fats omega-3 fatty acids, found in fish, nuts and certain seeds, are beneficial for heart health and can help manage diabetes.
Reducing simple sugars: Limiting foods with a high glycaemic index, such as sweets, sugary drinks and processed foods, is crucial to avoiding blood sugar spikes.
Hydration drinking enough water is essential for the metabolism and can help reduce appetite and calorie consumption.

By incorporating these elements into a daily diet, individuals can not only improve their weight management, but also effectively control their blood sugar levels, offering a natural and healthy alternative to medication. However, it is important to consult a healthcare professional or nutritionist for personalised advice, especially in the presence of medical conditions such as diabetes.

Physical activity: Exercise for weight loss and blood sugar control

Physical activity is a fundamental pillar in the management of obesity and type 2 diabetes. A well-designed exercise programme can not only help with weight loss, but also improve glycaemic control (2).

The importance of muscle mass

Muscle mass plays a crucial role not only in preventing metabolic diseases, but also in maintaining an active metabolism. A well-developed muscle has the particularity of consuming calories even when at rest, which contributes to greater energy expenditure on a daily basis. As Dr Gabrielle Lyon points out, most patients treated for obesity have low muscle mass, which can worsen their condition (1). As the body’s main endocrine organ, skeletal muscle is essential for survival and fighting disease. Dr Lyon recommends increased protein consumption, between 1.2 and 1.6 grams per kilogram of body weight per day, to promote muscle repair and construction.

Comparison between cardio and weight training

Cardiovascular training: Cardiovascular activities such as walking, running, cycling or swimming are effective for burning calories and improving heart health. They are particularly useful for reducing body fat and improving endurance.
Weight training: Weight training is essential for increasing muscle mass, which speeds up metabolism and improves body composition. Stronger muscles better support glucose metabolism and reduce the risk of metabolic diseases.

Recommended exercises

Strength training: Weight training: It is advisable to incorporate resistance exercises, such as dumbbells, weight machines or bodyweight exercises, at least three times a week. This is crucial, especially for women in the menopause, when muscle loss is accelerated.
Moderate cardiovascular activity: In addition to weight training, moderate cardiovascular exercise, totalling 200 to 300 minutes a week, is recommended to maintain weight loss.

Personalise your exercise programme

It is important to personalise the exercise programme according to individual preferences, motivation and life circumstances, while taking into account the person’s general state of health.

Long-term maintenance

For those who achieve their weight loss goals, it is recommended to follow long-term maintenance programmes that include regular monitoring and encourage continued physical activity.

Ozempic, Zepbound and Mounjaro: Choosing food supplements for metabolic syndrome

The use of natural supplements andplant extracts for weight management and blood sugar control is gaining in popularity. However, it is essential to understand which molecules and extracts have a proven track record in terms of efficacy, while taking safety considerations into account.

Effective molecules and extracts

Berberine: Berberine, often extracted from various plants, is recognised for its effectiveness in regulating blood sugar levels and lipid metabolism. It can be particularly useful for people suffering from type 2 diabetes or metabolic disorders. What’s more, it has long been used in Asia, demonstrating efficacy comparable to that of metformin comparable to that of metformin in the treatment of type 2 diabetes. One study highlighted its low cost and safety of use, as well as fewer side effects than other hypoglycaemic agents. However, it should be noted that existing studies have certain limitations, such as the small size of the population studied and the short follow-up period, which means that further research is needed to ensure long-term safety (9).
Fenugreek: Fenugreek, traditionally used in India in the Ayurvedic and Unani systems, has shown hypoglycaemic and anti-hyperlipidaemic properties in preliminary studies on animals and humans. One study revealed that treatment with fenugreek seed hydroalcoholic extract improved glycaemic control in non-insulin-dependent diabetic patients, with an improvement in insulin sensitivity and plasma lipid profile (10).
Chromium: A meta-analysis and systematic review examined the impact of chromium supplementation on conventional glycaemic control parameters in people with type 2 diabetes. Analysis of 28 randomised controlled studies showed that chromium supplementation led to a significant reduction in all the glycaemic parameters examined (fasting glycaemia, insulin, HbA1c, HOMA-IR) (11).

Building muscle to boost your metabolism (even at rest, watching Netflix)

Proteins, particularly through supplements, can help repair and build muscle, encouraging a more active metabolism. Clinical studies show that building muscle mass can have beneficial effects on metabolism and the prevention of certain diseases:

Effect on metabolism: Increasing muscle mass improves basal metabolic rate. Each additional kilogram of muscle requires energy to maintain, which means the body consumes more calories at rest. Increasing muscle mass through weight training therefore helps to maintain a high metabolic rate (14).
Impact on insulin sensitivity: Weight training improves insulin resistance, i.e. the ability of cells to react to insulin, a hormone responsible for maintaining normal blood sugar levels. This improvement can prevent type 2 diabetes. Muscle training increases the number of insulin receptors, making the body more efficient at producing less insulin to lower blood sugar levels.
Effects in obese adolescents: One study showed that weight training in obese adolescents, without calorie restriction, resulted in a significant reduction in body fat, an improvement in cardiorespiratory health, and a significant increase in insulin sensitivity, skeletal muscle mass and muscle strength. These results indicate that weight training may be particularly beneficial for metabolic health in obese adolescents (15).
Effects of ageing and the menopause: Ageing and the menopause are associated with an increase in fat mass and inflammation, as well as a decrease in muscle mass. These changes are linked to an increased risk of metabolic problems, in particular type 2 diabetes and cardiovascular disease. Research has highlighted the importance of muscle mass for good insulin sensitivity, although studies present divergent results and methodological inconsistencies. Moreover, physical capacity, linked to muscle mass, is an important determinant of health and quality of life in the elderly (16).

Safety considerations

It is crucial to adhere to the recommended doses to avoid side effects.
Supplements should not replace a balanced diet and a healthy lifestyle.
Consultation with a healthcare professional is recommended before starting any new supplement, particularly for people with existing medical conditions.

Selection of natural supplements for weight management and blood sugar control

Product	Key Ingredients	Main purpose
NHCO Symetix	Amino acids, chromium, plant extracts	Weight management
Aboca Metarecod	Plants for metabolic support	Metabolic syndrome
OligoMax Chromium	Chromium	Normal blood sugar
NHCO Aminosatyl	Active ingredients for satiety	Weight loss
Fenugreek – IPHYM seed	Fenugreek	Stimulate appetite, regulate glycaemia
Targedys Enterosatys	Intestinal microbiota	Weight management
Carbohydrate Metabolism Herbal Tea	Plants for sugar metabolism	Blood sugar stabilisation
Solaray Berberine	Berberine	Blood sugar, lipid metabolism

Towards personalised management of obesity and type 2 diabetes

The management of obesity and type 2 diabetes is a complex field that requires a personalised, multifactorial approach. A variety of treatment options are available, each with its own advantages, limitations and potential side-effects.

Summary of treatment options

GLP-1 and GIP drugs: Drugs such as tirzepatide (a dual agonist of the GIP and GLP-1 receptors) have shown significant efficacy in reducing body weight and improving glycaemic control in obese or overweight patients with type 2 diabetes. However, they can cause gastrointestinal side-effects and often require long-term use.
Diet and Nutrition: A balanced diet rich in fibre, lean protein and healthy fats, while limiting simple sugars, is crucial for weight management and blood sugar regulation.
Physical Activity: Regular exercise, including both strength training and cardiovascular activities, plays an essential role in weight loss, blood sugar control and the prevention of metabolic diseases.
Supplements and herbs: Certain supplements and herbs, such as berberine, fenugreek and chromium, can offer additional support for weight management and glycaemic control. However, their use should be supervised by a healthcare professional.

The importance of a personalised approach

Effective management of obesity and type 2 diabetes requires a personalised approach, taking into account each patient’s individual characteristics, health conditions, personal preferences and lifestyle. It is essential to work closely with healthcare professionals to develop a tailored treatment plan, which may include a combination of medication, diet modifications, exercise and supplements. This personalised approach helps to maximise results while minimising the risk of side effects and improving the patient’s quality of life.

In conclusion

Managing obesity and type 2 diabetes is a challenge that requires a thorough understanding of the various treatment options and a personalised approach for each patient. By combining judiciously chosen drug therapy with healthy lifestyle changes, it is possible to achieve effective control of weight and blood glucose levels, while improving the patient’s overall health and well-being.

Semaglutide + Tirzepatide: Our natural alternatives for obesity and diabetes