Shilajit: an effective supplement against Alzheimer’s?

Alzheimer’s disease, a progressive neurodegenerative disorder, affects millions of people worldwide. Characterised by memory loss, cognitive impairment and irreversible brain damage, the disease is a major challenge for modern medicine. However, recent research is highlighting promising natural solutions. Among these, Shilajit, an ancient substance in Ayurvedic medicine, stands out for its neuroprotective properties and its potential role in the fight against Alzheimer’s.

What is Shilajit and why is it unique?

Shilajit, often referred to as the ‘black gold of the Himalayas’, is a natural resin derived from the decomposition of organic matter in the mountains. It is rich in fulvic acids, dibenzo-alpha-pyrones and essential minerals, which contribute to its therapeutic properties. Used for centuries in Ayurvedic medicine to improve energy and longevity, it is now being studied for its role in protecting the neurons and slowing down neurodegenerative diseases, including Alzheimer’s.

The causes of Alzheimer’s disease and the mechanisms of Shilajit

Alzheimer’s disease is mainly caused by the accumulation of beta-amyloid plaques and abnormal Tau proteins in the brain. These pathological deposits seriously disrupt neuronal connections, leading to a loss of communication between nerve cells. This dysfunction leads to chronic brain inflammation, significant oxidative stress and, ultimately, the progressive death of neurons. These mechanisms, at the heart of the disease’s progression, are a major target for scientific research, with the aim of limiting the damage and improving patients’ cognitive function.

In this context, Shilajit offers a promising approach thanks to its multiple mechanisms of action. Fulvic acids, the key components of Shilajit, bind directly to beta-amyloid proteins, preventing their excessive aggregation. This process reduces the formation of amyloid plaques and protects synapses, improving communication between neurons and preserving cognitive function.

At the same time, Shilajit acts on Tau proteins, whose hyperphosphorylation destabilises neuronal structure. By inhibiting this process, Shilajit helps to maintain the integrity of neurons and slow cell degeneration. This action is particularly important in preserving brain connections and limiting memory loss associated with Alzheimer’s disease.

In addition, Shilajit’s bioactive compounds, such as dibenzo-alpha-pyrones, play a crucial role as powerful antioxidants. These molecules neutralise the free radicals responsible for oxidative stress, one of the main causes of neuronal damage in Alzheimer’s disease. By protecting brain cells from this stress, Shilajit helps to slow cell ageing and maintain neuronal health.

Finally, its anti-inflammatory properties help to reduce the chronic inflammation present in the brains of Alzheimer’s patients. By promoting a less hostile cerebral environment, Shilajit supports neuronal repair processes and improves the overall environment of nerve cells, offering greater protection against the progressive damage caused by the disease.

Together, these mechanisms show that Shilajit acts holistically to counter the destructive effects of Alzheimer’s disease, offering neurocerebral protection and significantly supporting cognitive function.

Clinical studies on Shilajit and Alzheimer’s disease

Scientific research confirms the beneficial effects of Shilajit on the brain. A study published in the Journal of Alzheimer’s Disease showed that the fulvic acids in Shilajit effectively reduced beta-amyloid deposits in preclinical models, slowing the progression of the disease. Other studies have shown that regular intake of Shilajit improves memory and cognition, particularly in the early stages of the disease. (1)

Another study revealed that Shilajit increases the production of ATP (cellular energy) in the mitochondria of brain cells, which helps to improve neuronal function and prevent the energy depletion associated with Alzheimer’s disease. These results show that Shilajit may be a promising supplement for patients with mild or moderate cognitive impairment.

How can Shilajit be used for cognitive support?

To reap the benefits of Shilajit for brain health, it is recommended that you consume 250 to 500 mg of purified Shilajit a day. Taking it regularly for 8 to 12 weeks is ideal for seeing improvements in memory and concentration. However, it is essential to consult a health professional before adding Shilajit to your routine, especially for people already undergoing medical treatment for Alzheimer’s.

Shilajit can also be combined with a diet rich in omega-3s, antioxidants (such as red fruit) and B vitamins, which support brain health and reinforce the neuroprotective effects of this natural supplement.

Read more:

1. Andrade V, Wong-Guerra M, Cortés N, Pastor G, González A, Calfío C, Guzmán-Martínez L, Navarrete LP, Ramos-Escobar N, Morales I, Santander R, Andrades-Lagos J, Bacho M, Rojo LE, Maccioni RB. Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer’s Disease. Pharmaceuticals (Basel). 2023 Jul 4;16(7):960. doi: 10.3390/ph16070960. PMID: 37513872; PMCID: PMC10383824.