Glutathione is needed in many stages of the immune response . High levels of glutathione therefore allow the body to produce more white blood cells constituting the first line of defense of the immune system. Glutathione is thus essential for the multiplication of the lymphocytes necessary for the development of a strong immune response and for the killer lymphocytes (NK) to be able to destroy unwanted cells. In this article we will talk about the impact of micro-nutritional deficiencies and excesses on the morbidity and lethality of Covid-19 requiring precise and personalized care. Indeed, a micro-nutritional monitoring schemewould in fact limit the severity of the disease, as well as prepare patients who are vaccinated for better vaccine effectiveness .
What is the role of Glutathione in the body?
Glutathione is a tripeptide made up of 3 amino acids: cysteine , glycine and glutamate . It contributes to the health of the body and the lungs, and also plays a central role in the protection of cells against cellular damage induced by oxidative stress, but also in the detoxification of xenobiotics and drug metabolism.
The role of glutathione is to regulate the balance between innate immunity and inflammation , but also the infiltration of leukocytes at the site of infection to kill bacteria.
What is the link between Glutathione and Covid-19?
The Covid-19, but also its vaccine feed on this glutathione and do not hesitate to draw on our reserves; thus giving rise to a wide range of pathological conditions. Resistance to viral diseases therefore correlates positively with the extent of glutathione stores.
The risk factors for severe infection Covid-19 are in fact associated with a decrease or depletion of intracellular glutathione .
On the contrary, higher levels of glutathione have been associated with better individual responsiveness to viral infections . Glutathione is in fact known to protect host immune cells operating in oxidative stress environments, while contributing to their optimal functioning.
What are the risks of a Glutathione deficiency during Covid-19 contamination?
Alveolar fluid glutathione deficiency in patients with pulmonary edema or respiratory distress (ARDS) linked to Covid-19, has been shown to correlate with increased damage and inflammation of mediated lung cells by ROS ( Reactive Oxygen Species ). Incidentally, ARDS and the cytokine storm characterize the late stages of Covid-19.
A glutathione deficiency therefore leads to the activation of von Willebrand factor and the accumulation of ROS, which affect coagulation and platelet activation , impair endothelial function and predispose to the risk of thrombotic events , in particular hypercoagulation; a significant life-threatening complication in patients with Covid-19.
Why is it recommended to take a Glutathione cure during a Covid-19 contamination or as part of the Covid vaccination?
Low plasma glutathione levels have been identified along with three other clinical indicators (age, CD3 ratio and total protein) as a predictor of severe / critical symptoms in patients infected with COVID-19. All of this data has clinical relevance: Polonikov , studying 4 cases of moderate to severe COVID-19, found that while the three patients with high normal plasma glutathione levels recovered quickly, the one with low glutathione levels, high plasma ROSs and ROS / GSH ratio was suffering from the most severe disease and, at the time of publication, was still ill.
In another case report, 2 patients with COVID-19 pneumonia were successfully treated with high doses of supplemental intravenous glutathione and oral N-acetylcysteine; finally, Ibrahim et al. reported the case of a group of 9 critically ill patients successfully treated with N-acetylcysteine. Glutathione and acetylcysteine thus represent two nutrients that are useful and effective in the management of COVID-19 patients.
Total Glutathione Determination and Oral Supplementation
Although glycine is considered a non-essential amino acid because our body is able to produce it from other amino acids, this endogenous synthesis is not enough to cover all of our needs. Thus, glycine supplementation appears crucial to boost the body’s glutathione levels and thus attenuate the effects of the passage of time, and it has shown its interest in the context of various pathological situations. The ideal would therefore be to provide large amounts of glycine (5 to 10 g per day) and moderate amounts of acetylcysteine (200 to 400 mg per day).
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